@booklet {3852,
	title = {Formulations for poorly soluble drugs comprising hydrophilic polymers.},
	howpublished = {PCT Int. Appl.},
	number = {WO2005072709A2},
	year = {2005},
	note = {CAPLUS AN 2005:732592(Patent)},
	month = {2005/08/11/},
	pages = {36 pp.},
	publisher = {Bio Dar Ltd., Israel; Yissum Research Development Company of the Hebrew University of Jerusalem .},
	abstract = {{The present invention provides a drug delivery system comprising nanoparticles or microparticles of a water poorly sol. drug dispersed in a polymeric bead contg. essentially only of hydrophilic polymers (i.e., without hydrophobic polymers). The present invention further provides a method of producing the drug delivery system of the invention. Thus, a 4\% sodium alginate soln. was prepd. by mixing 16 g of sodium alginate and 400 g water together with 0.4 g of Bronopol (preservative) at about 37{\textdegree} until complete dissoln. A crosslinking agent was prepd. by dissolving 14.8 g of calcium chloride dihydrate in 1000 g water. An oil-in-water emulsion (20\% oil phase, 80\% aq. phase) was prepd. contg. 3\% surfactant (mixt. of Tween 20 and Span 20},
	keywords = {polymer hydrophilicity poorly soluble drug particle},
	author = {Magdassi, Shlomo and Sela, Yoram and Cohen, Keren.}
}
