@booklet {3850,
	title = {Biocompatible polymeric delivery systems for sustained release of quinazolinones.},
	howpublished = {PCT Int. Appl.},
	number = {WO2005079703A1},
	year = {2005},
	note = {CAPLUS AN 2005:961994(Patent)},
	month = {2005/09/01/},
	pages = {59 pp.},
	publisher = {Collgard Biopharmaceuticals Ltd., Israel .},
	abstract = {The present invention relates to biocompatible polymeric delivery systems for controlled or sustained release of quinazolinone derivs.(I; n = 1-2; R1 = H, halo, NO2, benzo, alkyl, Ph, alkoxy; R2 = OH, acetoxy, alkoxy; R3 = H, alkenoxy carbonyl), including the compd. halofuginone. In particular the invention relates to a polymeric delivery system comprising biocompatible polymeric beads having a two-phase core and shell structure, or polymeric films, beads or complexes that provide local sustained release of the pharmacol. agent. For example, polymeric emulsion beads with core/shell structure were prepd. for controlled release of halofuginone. A water-in-oil emulsion was prepd., in which the 20\% wt. internal phase contained 50 mg halofuginone HBr/mL and the oil was sunflower oil. The emulsion was prepd. by adding the aq. halofuginone soln. in to the oil which contains 2.7\% wt. span 80, and homogenized. Beads were formed by a core-shell double nozzle Innotek. The shell soln. was 2.5\% sodium alginate and 2.5\% silica in aq. soln. [on SciFinder(R)]},
	keywords = {halofuginone polymer bead film sustained release, quinazolinone polymer bead film sustained release},
	author = {Magdassi, Shlomo and Cohn, Daniel.}
}
