@booklet {3965,
	title = {Dispersions in oil of Dead Sea nano sized material preparation and uses thereof in topical application.},
	howpublished = {U.S. Pat. Appl. Publ.},
	number = {US20130236571A1},
	year = {2013},
	note = {CAPLUS AN 2013:1417149(Patent)},
	month = {2013/09/12/},
	pages = {26pp.},
	publisher = {Dead Sea Laboratories Ltd., Israel; Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. .},
	abstract = {The present disclosure is directed to dispersions of a Dead Sea material in oil, the Dead Sea material is present in the dispersions in the form of solid nanoparticles. Further disclosed are formulations comprising the dispersions, method of treating and/or preventing diseases or disorders of the skin comprising topical application of the dispersions or formulations thereof onto a skin of a subject, method of inducing a heat sensation on the skin of a subject by topically applying the dispersions or formulations thereof onto a skin of a subject and methods of prepg. the dispersions. Thus, an oil phase was prepd. by dissolving 1.8 g (9 wt\%) Abil Em 90 in 11.48 g (57.4 wt\%) cyclomethicone, 1 g (5 wt\%) DOW 9041, 0.02 g (0.1 wt\%) Vitamin E Acetate and 0.2 g (1 wt\%) Retinyl palmitate mixt.; an aq. phase was prepd. by adding a 0.5 g (2.5 wt\%) Dead Sea water (40 \% dead sea salt, 1 \% DSS final concn.) to 4.2 g (21 wt\%) deionized water, 0.2 g (1 wt\%) glycerol, 0.4 g (2 wt\%) 1,3-propane diol and 0.2 g (1 wt\%) PVP (MW = 40000); the total wt. of water and oil phase was 20 g; the aq. phase was added to the oil phase while being mixed for 10 min with a high speed homogenizer at a speed of 13000 rpm with or without addnl. sonication; the nanoparticles were obtained by water evapn. at reduced pressure (15 mbar, 50 {\textdegree}C for 40 min); the nanoparticles size obtained in the two processes, with and without sonication, measured by DLS was 99 nm and 255 nm, resp. [on SciFinder(R)]},
	keywords = {Dead Sea oil nanoparticle dispersion topical skin heat sensation},
	author = {Magdassi, Shlomo and Larush, Liraz and Mendelson, Chani and Oron, Miriam and Maor, Zeevi and Afriat-Staloff, Isabelle Rachel and Privorotski, Marina.}
}
