@article {3610,
	title = {Formation of curcumin nanoparticles by flash nanoprecipitation from emulsions},
	journal = {Journal of Colloid And Interface Science},
	volume = {434},
	year = {2014},
	note = {Accession Number: S0021979714005384; Author: Margulis, Katherine (a, ⁎); Author: Magdassi, Shlomo (a); Author: Lee, Han Seung (b); Author: Macosko, Christopher W. (b); Affiliation: Casali Institute of Applied Chemistry, Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel; Affiliation: Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA; Number of Pages: 6; Language: English;},
	month = {2014/11/15/15 No},
	pages = {65 - 70},
	publisher = {Elsevier Inc.},
	abstract = {{\textbullet}A new method for production of organic nanoparticles is demonstrated for curcumin.{\textbullet}The method is based on flash nanoprecipitation from partially water-soluble emulsions.{\textbullet}A simple hand-operated mixer is employed for flash nanoprecipitation process.{\textbullet}Dry nanometric powders obtained by spray drying are easily dispersible in water.{\textbullet}The resultant particles are 40nm in diameter and contain above 20wt\% active substance.Nanometric particles of a model hydrophobic substance curcumin were prepared by a novel method, namely, flash nanoprecipitation from a coarse oil-in-water emulsion. The method employs turbulent co-mixing of water with curcumin-loaded emulsion using manually-operated confined impingement jets mixer. A clear and stable dispersion of nanoparticles was formed in this process, and could be converted to dry, easily water-dispersible powder by spray drying. The mean size of the particles was about 40nm by DLS, confirmed by Cryo-TEM. The obtained particles contained 20.4wt\% curcumin, X-ray analysis showed it was amorphous. The significant advantages of the studied process are its feasibility, speed and low cost. It does not require any special high-energy input equipment to reduce the droplet size of the initial emulsion as required by the vast majority of other methods, and relies on rapid turbulent mixing and on flow-induced shear stress formed in the simple, manually-operated mixer. Control experiments clearly indicate that employing emulsion, instead of a plain solution and flash nanoprecipitation instead of a simple antisolvent precipitation are advantageous in terms of particle size and stability.},
	isbn = {0021-9797},
	url = {http://search.ebscohost.com/login.aspx?direct=true\&db=edselp\&AN=S0021979714005384\&site=eds-live},
	author = {Margulis, Katherine and Magdassi, Shlomo and Lee, Han Seung and Macosko, Christopher W.}
}
