Abstract:

Ensuring drug loading efficiency and consistency is one of the most critical stages in engineering drug delivery vectors based on porous materials. Here we propose a technique to significantly enhance the efficiency of loading by employing simple and widely available methods: applying low pressure with and without centrifugation. Our results point toward the advantages the proposed method over the passive loading, especially where the size difference of loaded materials and the pore size of the porous silicon particles is smaller, an increase up to 20-fold can be observed. The technique described in the study can be used for efficient and reproducible loading of porous materials with therapeutic molecules, nanoparticles and contrast imaging agents for biomedical application.;

Notes:

Accession Number: 25485265. Language: English. Date Revised: 20141210. Date Created: 20141208. Update Code: 20150624. Publication Type: JOURNAL ARTICLE. Journal ID: 101634696. Publication Model: Print. Cited Medium: Print. NLM ISO Abbr: Mesoporous Biomater. Grant Information: U54 CA143837 United States CA NCI NIH HHS; U54 CA151668 United States CA NCI NIH HHS Date of Electronic Publication: 20140101. ; Original Imprints: Publication: Berlin : De Gruyter